Why I Hate L Proline
148.00 £
Published date: 2025/03/03
- Location: 3652, Woonsocket, Illinois, United States
From a kinetic standpoint, Cis-trans proline isomerization is a very sluggish process that may impede the progress of protein folding by trapping a number of prolines essential for folding within the nonnative isomer, particularly when the native protein requires the cis isomer. Hence, the fraction of X-Pro peptide bonds in the cis isomer underneath unstrained situations ranges from 10-40%; the fraction relies upon slightly on the preceding reliable amino acids manufacturer acid X, with aromatic residues favoring the cis isomer barely. By distinction, the cis and trans isomers of the X-Pro peptide bond both experience steric clashes with the neighboring subtitution and are almost equally energetically disfavorable.
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